Publications

Daria Antonenko, Agnes Flöel, Chapter 25 - Noninvasive transcranial brain stimulation to treat mild cognitive impairment & dementia, Editor(s): Vincent Van Waes, Jean-Pascal Lefaucheur, Andrea Antal, Alexander T. Sack, Chris Baeken,
Handbook of Behavioral Neuroscience, Elsevier, Volume 34, 2025, Pages 437-458, ISSN 1569-7339, ISBN 9780443266027,
https://doi.org/10.1016/B978-0-443-26602-7.00026-9. 

Kocataş H, …, Meinzer M. Functionally Relevant and Reliable Brain Stimulation Targets for Enhancement of Novel Word-Learning. bioRxiv 2025.11.04.686295; doi: https://doi.org/10.1101/2025.11.04.686295.

Gräfe J, Wang P, Antonenko D, Flöel A, Limanowski J. Occipital tACS does not modulate manual performance but fixation variability under visuo-proprioceptive conflict. bioRxiv 2025.12.08.693038; doi: https://doi.org/10.64898/2025.12.08.693038.

Kimura I, Meinzer M, Antonenko D, Darkow R, Flöel A, Thielscher A. Simulating tDCS-induced electric fields in stroke patients: Realistic-lesion head models are needed. Neuroimage Clin. 2025 Dec 23;49:103931. doi: 10.1016/j.nicl.2025.103931.

Nejati V, Vaziri Z, Antal A, Antonenko D, Behroozmand R, Bestmann S, Brunelin J, Brunoni AR, Carvalho S, Davis NJ, Enticott PG, Fallgatter AJ, Ferrucci R, Fitzgerald PB, Hamada M, Hamilton RH, Hoy KE, Jaberzadeh S, Jamil A, Cohen Kadosh R, Krekelberg B, Laureys S, Romero Lauro LJ, Loo CK, Martin D, Martinotti G, Mondino M, Oliviero A, Pellicciari MC, Plewnia C, Pobric G, De Raedt R, Razza LB, Rocchi L, Salehinejad MA, Khorrami AS, Schecklmann M, Siebner HR, Taylor SF, Vanderhasselt MA, Vanneste S, Vicario CM, Woods AJ, Ziemann U, Nitsche MA. Report Approval for Transcranial Electrical Stimulation (RATES): expert recommendation based on a Delphi consensus study. Nat Protoc. 2025 Oct 3. https://doi.org/10.1038/s41596-025-01259-0

Ehrhardt NM, Hanna J, Hayek D, Fleischmann R, Grittner U, Thielscher A, Flöel A, Antonenko D. Memory dependent modulation of hippocampal theta power through frontoparietal phase synchronous brain stimulation. Sci Rep. 2025 Jul 21;15(1):26504. doi: 10.1038/s41598-025-09841-y. 

Tsvetkov D, Meyer-Tönnies MJ, Tzvetkov MV, Weitschies W, Engeli S, Lebedeva A, Hannemann A, Jordan MC, Garscha U, Valentini L, Antonenko D, Kennes LN, Gollasch M. Effective Therapeutic Strategies to Prevent Frailty and Falls in Community-Dwelling Older Adults. Aging Dis. 2025 Jun 17. doi: 10.14336/AD.2025.0445.

Abdelmotaleb M, Niemann F, Kocataş H, Caisachana Guevara LM, Shahbabaie A, Malinowski R, Riemann S, Fromm AE, Hayek D, Antonenko D, Meinzer M, Flöel A. Identification of Reliable Target Brain Regions for Enhancing Object-Location Memory by Brain Stimulation. Brain Behav. 2025 Jul;15(7):e70658. doi: 10.1002/brb3.70658. 

Fromm AE, Trujillo-Llano C, Grittner U, Meinzer M, Flöel A, Antonenko D. Increased variability in response to transcranial direct current stimulation in healthy older compared to young adults: A systematic review and meta-analysis. Brain Stimul. 2025 Jul 8;18(4):1257-1265. doi: 10.1016/j.brs.2025.06.005.

Rocke M, Knochenhauer E, Thams F, Antonenko D, Fromm AE, Jansen N, Aziziaram S, Grittner U, Schmidt S, Vogelgesang A, Brakemeier EL, Flöel A. Neuromodulation through brain stimulation-assisted cognitive training in patients with post-chemotherapy subjective cognitive impairment (Neuromod-PCSCI) after breast cancer: study protocol for a double-blinded randomised controlled trial. BMJ Open. 2025 May 21;15(5):e096162. doi: 10.1136/bmjopen-2024-096162. 

Antonenko D, Thielscher A. Individualisierte Neuromodulation kognitiver Funktionen im Kontext der Hirnalterung. Neuroforum, Organ der Neurowissenschaftlichen Gesellschaft. 2025 Jun 2; 31(2). e-ISSN 2363-7013.

Leroy S, Bublitz V, von Dincklage F, Antonenko D, Fleischmann R. Normative characterization of age-related periodic and aperiodic activity in resting-state real-world clinical EEG recordings. Front Aging Neurosci. 2025 Apr 11;17:1540040. doi: 10.3389/fnagi.2025.1540040. 

Antonenko D, Leroy S, Müller J, Behr F, Fromm AE, von Dincklage F, Fleischmann R. Large-scale network mechanisms underlying postoperative cognitive improvement after spine surgery. Int J Surg. 2025 Jan 8. doi: 10.1097/JS9.0000000000002210. 

Leroy S, Bublitz V, Grittner U, Fleischmann R, von Dincklage F, Antonenko D. Modulating delirium through stimulation (MoDeSt): study protocol for a randomized, double-blind, sham-controlled trial assessing the effect of postoperative transcranial electrical stimulation on delirium incidence. Trials. 2025 Jan 3;26(1):4. doi: 10.1186/s13063-024-08699-1. 

Niemann F, Shahbabaie A, Paßmann S, Riemann S, Malinowski R, Kocataş H, Caisachana Guevara LM, Abdelmotaleb M, Antonenko D, Blankenburg F, Fischer R, Hartwigsen G, Li SC, Nitsche MA, Thielscher A, Timmann D, Fromm A, Hayek D, Hubert AK, Martin AK, Hunold A, Flöel A, Meinzer M. Neuronavigated Focalized Transcranial Direct Current Stimulation Administered During Functional Magnetic Resonance Imaging. J Vis Exp. 2024 Nov 15;(213). doi: 10.3791/67155.

Rocke M, Fromm AE, Jansen N, Thams F, Trujillo-Llano C, Grittner U, Antonenko D, Flöel A. Feasibility and pilot efficacy of self-applied home-based cognitive training and brain stimulation: A randomized-controlled trial. Brain Stimul. 2024 Oct 30;17(6):1241-1243. doi: 10.1016/j.brs.2024.10.009.

Ehrhardt NM, Niehoff C, Oßwald AC, Antonenko D, Lucchese G, Fleischmann R. Comparison of dry and wet electroencephalography for the assessment of cognitive evoked potentials and sensor-level connectivity. Front Neurosci. 2024 Nov 6;18:1441799. doi: 10.3389/fnins.2024.1441799.

Leroy S, Bublitz V, von Dincklage F, Antonenko D, Fleischmann R. Normative characterization of age-related periodic and aperiodic activity in resting-state clinical EEG recordings. medRxiv [Preprint]. 2024 June 19; https://doi.org/10.1101/2024.06.18.24308910.

Fromm AE, Antonenko D. The potential compensatory effect of transcranial electrical stimulation on the adverse impact of white matter damage in the aging brain. Brain Stimul. 2024 May 27;17(3):681-682. doi: 10.1016/j.brs.2024.05.011. 

Meinzer M et al. Investigating the neural mechanisms of transcranial direct current stimulation effects on human cognition: Current issues and potential solutions. Front. Neurosci. Volume 18, 2024, doi:10.3389/fnins.2024.1389651.

Fromm AE, Grittner U, Brodt S, Flöel A, Antonenko D. No object-location memory improvement through focal transcranial direct current stimulation over the right temporoparietal cortex. Life, 2024, 14, 539, https://doi.org/10.3390/life14050539.

Niemann F, Riemann S, Hubert AK, Antonenko D, Thielscher A, Martin AK, Unger N, Flöel A, Meinzer M.
Electrode positioning errors reduce current dose for focal tDCS set-ups: Evidence from individualized electric field mapping. Clinical Neurophysiol, 2024, https://doi.org/10.1016/j.clinph.2024.03.031.

Ehrhardt NM, Flöel A, Li SC, Lucchese G, Antonenko D. Brain oscillatory processes related to sequence memory in healthy older adults. Neurobiol Aging, 2024, 139:64-72. https://doi.org/10.1016/j.neurobiolaging.2024.04.001.

Kang K, Antonenko D, Glöckner F, Flöel A, Li SC. Neural correlates of home-based intervention effects on value-based sequential decision-making in healthy older adults. Aging Brain, 2024, Vol 5, 100109. https://doi.org/10.1016/j.nbas.2024.100109.

Antonenko D, Fromm AE, Thams F, Kuzmina A, Backhaus M, Knochenhauer E, Li SC, Grittner U, Flöel A. Cognitive training and brain stimulation in patients with cognitive impairment: a randomized controlled trial. Alzheimers Res Ther. 2024 Jan 11;16(1):6. doi: 10.1186/s13195-024-01381-3. 

Wüst LN, Antonenko D, Malinowski R, Khakimova L, Grittner U, Obermayer K, Ladenbauer J, Flöel A. Interrelations and functional roles of key oscillatory activities during daytime sleep in older adults. J Sleep Res. 2023 Jul 24. doi: 10.1111/jsr.13981. 

Thams F, Li SC, Flöel A, Antonenko D. Functional Connectivity and Microstructural Network Correlates of Interindividual Variability in Distinct Executive Functions of Healthy Older Adults. Neuroscience. 2023 Aug 21;526:61-73. doi: 10.1016/j.neuroscience.2023.06.005. 

Antonenko D, Fromm AE, Thams F, Grittner U, Meinzer M, Flöel A. Microstructural and functional plasticity following repeated brain stimulation during cognitive training in older adults. Nat Commun. 2023 Jun 2;14(1):3184. doi: 10.1038/s41467-023-38910-x. 

Mahesan D, Antonenko D, Flöel A, Fischer R. Modulation of the executive control network by anodal tDCS over the left dorsolateral prefrontal cortex improves task shielding in dual tasking. Sci Rep. 2023 Apr 15;13(1):6177. doi: 10.1038/s41598-023-33057-7.

Ladenbauer J, Khakimova L, Malinowski R, Obst D, Tönnies E, Antonenko D, Obermayer K, Hanna J, Flöel A. Towards Optimization of Oscillatory Stimulation During Sleep. Neuromodulation. 2023 Dec;26(8):1592-1601. doi: 10.1016/j.neurom.2022.05.006. 

Antonenko D, Rocke M, Thams F, Hummel FC, Maceira-Elvira P, Meinzer M, Flöel A. Complementary practical considerations to home-based, remotely-controlled and independently self-applied tES combined with cognitive training. Brain Stimul. 2022 Nov-Dec;15(6):1351-1353. doi: 10.1016/j.brs.2022.09.010. 

Thams F, Rocke M, Malinowski R, Nowak R, Grittner U, Antonenko D, Flöel A. Feasibility of Cognitive Training in Combination With Transcranial Direct Current Stimulation in a Home-Based Context (TrainStim-Home): study protocol for a randomised controlled trial. BMJ Open. 2022 Jun 10;12(6):e059943. doi: 10.1136/bmjopen-2021-059943. 

Schwarz C, Benson GS, Antonenko D, Horn N, Köbe T, Klimecki O, Sommer W, Wirth M, Flöel A. Negative affective burden is associated with higher resting-state functional connectivity in subjective cognitive decline. Sci Rep. 2022 Apr 13;12(1):6212. doi: 10.1038/s41598-022-10179-y. 

Thams F, Antonenko D, Fleischmann R, Meinzer M, Grittner U, Schmidt S, Brakemeier EL, Steinmetz A, Flöel A. Neuromodulation through brain stimulation-assisted cognitive training in patients with post-COVID-19 cognitive impairment (Neuromod-COV): study protocol for a PROBE phase IIb trial. BMJ Open. 2022 Apr 11;12(4):e055038. doi: 10.1136/bmjopen-2021-055038. 

Thams F, Külzow N, Flöel A, Antonenko D. Modulation of network centrality and gray matter microstructure using multi-session brain stimulation and memory training. Hum Brain Mapp. 2022 Aug 1;43(11):3416-3426. doi: 10.1002/hbm.25857.

Antonenko D, Thams F, Grittner U, Uhrich J, Glöckner F, Li SC, Flöel A. Randomized trial of cognitive training and brain stimulation in non-demented older adults. Alzheimers Dement (N Y). 2022 Feb 23;8(1):e12262. doi: 10.1002/trc2.12262.

Ekhtiari H, Ghobadi-Azbari P, Thielscher A, Antal A, Li LM, Shereen AD, Cabral-Calderin Y, Keeser D, Bergmann TO, Jamil A, Violante IR, Almeida J, Meinzer M, Siebner HR, Woods AJ, Stagg CJ, Abend R, Antonenko D, Auer T, Bächinger M, Baeken C, Barron HC, Chase HW, Crinion J, Datta A, Davis MH, Ebrahimi M, Esmaeilpour Z, Falcone B, Fiori V, Ghodratitoostani I, Gilam G, Grabner RH, Greenspan JD, Groen G, Hartwigsen G, Hauser TU, Herrmann CS, Juan CH, Krekelberg B, Lefebvre S, Liew SL, Madsen KH, Mahdavifar-Khayati R, Malmir N, Marangolo P, Martin AK, Meeker TJ, Ardabili HM, Moisa M, Momi D, Mulyana B, Opitz A, Orlov N, Ragert P, Ruff CC, Ruffini G, Ruttorf M, Sangchooli A, Schellhorn K, Schlaug G, Sehm B, Soleimani G, Tavakoli H, Thompson B, Timmann D, Tsuchiyagaito A, Ulrich M, Vosskuhl J, Weinrich CA, Zare-Bidoky M, Zhang X, Zoefel B, Nitsche MA, Bikson M. A checklist for assessing the methodological quality of concurrent tES-fMRI studies (ContES checklist): a consensus study and statement. Nat Protoc. 2022 Mar;17(3):596-617. doi: 10.1038/s41596-021-00664-5.

Antonenko D, Grittner U, Puonti O, Flöel A, Thielscher A. Estimation of individually induced e-field strength during transcranial electric stimulation using the head circumference. Brain Stimul. 2021 Sep-Oct;14(5):1055-1058. doi: 10.1016/j.brs.2021.07.001.

Hayek D, Antonenko D, Witte AV, Lehnerer SM, Meinzer M, Külzow N, Prehn K, Rujescu D, Schneider A, Grittner U, Flöel A. Impact of COMT val158met on tDCS-induced cognitive enhancement in older adults. Behav Brain Res. 2021 Mar 5;401:113081. doi: 10.1016/j.bbr.2020.113081.

Antonenko D, Grittner U, Saturnino G, Nierhaus T, Thielscher A, Flöel A. Inter-individual and age-dependent variability in simulated electric fields induced by conventional transcranial electrical stimulation. Neuroimage. 2021 Jan 1;224:117413. doi: 10.1016/j.neuroimage.2020.117413. 

Thams F, Kuzmina A, Backhaus M, Li SC, Grittner U, Antonenko D, Flöel A. Cognitive training and brain stimulation in prodromal Alzheimer’s disease (AD-Stim)-study protocol for a double-blind randomized controlled phase IIb (monocenter) trial. Alzheimers Res Ther. 2020 Nov 7;12(1):142. doi: 10.1186/s13195-020-00692-5.

Habich A, Fehér KD, Antonenko D, Boraxbekk CJ, Flöel A, Nissen C, Siebner HR, Thielscher A, Klöppel S. Stimulating aged brains with transcranial direct current stimulation: Opportunities and challenges. Psychiatry Res Neuroimaging. 2020 Dec 30;306:111179. doi: 10.1016/j.pscychresns.2020.111179.

Liebrand M, Karabanov A, Antonenko D, Flöel A, Siebner HR, Classen J, Krämer UM, Tzvi E. Beneficial effects of cerebellar tDCS on motor learning are associated with altered putamen-cerebellar connectivity: A simultaneous tDCS-fMRI study. Neuroimage. 2020 Dec;223:117363. doi: 10.1016/j.neuroimage.2020.117363. 

Hayek D, Thams F, Flöel A, Antonenko D. Dentate Gyrus Volume Mediates the Effect of Fornix Microstructure on Memory Formation in Older Adults. Front Aging Neurosci. 2020 Mar 20;12:79. doi: 10.3389/fnagi.2020.00079. 

Antonenko D, Thielscher A, Saturnino GB, Aydin S, Ittermann B, Grittner U, Flöel A. Towards precise brain stimulation: Is electric field simulation related to neuromodulation? Brain Stimul. 2019 Sep-Oct;12(5):1159-1168. doi: 10.1016/j.brs.2019.03.072. 

Antonenko D, Thams F, Uhrich J, Dix A, Thurm F, Li SC, Grittner U, Flöel A. Effects of a Multi-Session Cognitive Training Combined With Brain Stimulation (TrainStim-Cog) on Age-Associated Cognitive Decline – Study Protocol for a Randomized Controlled Phase IIb (Monocenter) Trial. Front Aging Neurosci. 2019 Aug 16;11:200. doi: 10.3389/fnagi.2019.00200. 

Saturnino GB, Puonti O, Nielsen JD, Antonenko D, Madsen KH, Thielscher A. SimNIBS 2.1: A Comprehensive Pipeline for Individualized Electric Field Modelling for Transcranial Brain Stimulation. 2019 Aug 28. In: Makarov S, Horner M, Noetscher G, editors. Brain and Human Body Modeling: Computational Human Modeling at EMBC 2018 [Internet]. Cham (CH): Springer; 2019. Chapter 1.

Antonenko D, Hayek D, Netzband J, Grittner U, Flöel A. tDCS-induced episodic memory enhancement and its association with functional network coupling in older adults. Sci Rep. 2019 Feb 19;9(1):2273. doi: 10.1038/s41598-019-38630-7. 

Hayek D, Flöel A, Antonenko D. Role of Sensorimotor Cortex in Gestural-Verbal Integration. Front Hum Neurosci. 2018 Dec 6;12:482. doi: 10.3389/fnhum.2018.00482.

Antonenko D, Nierhaus T, Meinzer M, Prehn K, Thielscher A, Ittermann B, Flöel A. Age-dependent effects of brain stimulation on network centrality. Neuroimage. 2018 Aug 1;176:71-82. doi: 10.1016/j.neuroimage.2018.04.038. 

Strobach T, Antonenko D, Abbarin M, Escher M, Flöel A, Schubert T. Modulation of dual-task control with right prefrontal transcranial direct current stimulation (tDCS). Exp Brain Res. 2018 Jan;236(1):227-241. doi: 10.1007/s00221-017-5121-2. 

Antonenko D, Külzow N, Sousa A, Prehn K, Grittner U, Flöel A. Neuronal and behavioral effects of multi-day brain stimulation and memory training. Neurobiol Aging. 2018 Jan;61:245-254. doi: 10.1016/j.neurobiolaging.2017.09.017. 

Gerischer LM, Fehlner A, Köbe T, Prehn K, Antonenko D, Grittner U, Braun J, Sack I, Flöel A. Combining viscoelasticity, diffusivity and volume of the hippocampus for the diagnosis of Alzheimer’s disease based on magnetic resonance imaging. Neuroimage Clin. 2017 Dec 20;18:485-493. doi: 10.1016/j.nicl.2017.12.023. 

Antonenko D, Schubert F, Bohm F, Ittermann B, Aydin S, Hayek D, Grittner U, Flöel A. tDCS-Induced Modulation of GABA Levels and Resting-State Functional Connectivity in Older Adults. J Neurosci. 2017 Apr 12;37(15):4065-4073. doi: 10.1523/JNEUROSCI.0079-17.2017.

Ladenbauer J, Külzow N, Passmann S, Antonenko D, Grittner U, Tamm S, Flöel A. Brain stimulation during an afternoon nap boosts slow oscillatory activity and memory consolidation in older adults. Neuroimage. 2016 Nov 15;142:311-323. doi: 10.1016/j.neuroimage.2016.06.057.

Antonenko D, Faxel M, Grittner U, Lavidor M, Flöel A. Effects of Transcranial Alternating Current Stimulation on Cognitive Functions in Healthy Young and Older Adults. Neural Plast. 2016;2016:4274127. doi: 10.1155/2016/4274127.

Paßmann S, Külzow N, Ladenbauer J, Antonenko D, Grittner U, Tamm S, Flöel A. Boosting Slow Oscillatory Activity Using tDCS during Early Nocturnal Slow Wave Sleep Does Not Improve Memory Consolidation in Healthy Older Adults. Brain Stimul. 2016 Sep-Oct;9(5):730-739. doi: 10.1016/j.brs.2016.04.016.

Antonenko D, Külzow N, Cesarz ME, Schindler K, Grittner U, Flöel A. Hippocampal Pathway Plasticity Is Associated with the Ability to Form Novel Memories in Older Adults. Front Aging Neurosci. 2016 Mar 22;8:61. doi: 10.3389/fnagi.2016.00061. 

Strobach T, Soutschek A, Antonenko D, Flöel A, Schubert T. Modulation of executive control in dual tasks with transcranial direct current stimulation (tDCS). Neuropsychologia. 2015 Feb;68:8-20. doi: 10.1016/j.neuropsychologia.2014.12.024.

Antonenko D, Flöel A. Healthy aging by staying selectively connected: a mini-review. Gerontology. 2014;60(1):3-9. doi: 10.1159/000354376. 

Meinzer M, Lindenberg R, Antonenko D, Flaisch T, Flöel A. Anodal transcranial direct current stimulation temporarily reverses age-associated cognitive decline and functional brain activity changes. J Neurosci. 2013 Jul 24;33(30):12470-8. doi: 10.1523/JNEUROSCI.5743-12.2013.

Antonenko D, Brauer J, Meinzer M, Fengler A, Kerti L, Friederici AD, Flöel A. Functional and structural syntax networks in aging. Neuroimage. 2013 Dec;83:513-23. doi: 10.1016/j.neuroimage.2013.07.018. 

Thurm F, Antonenko D, Schlee W, Kolassa S, Elbert T, Kolassa IT. Effects of aging and mild cognitive impairment on electrophysiological correlates of performance monitoring. J Alzheimers Dis. 2013;35(3):575-87. doi: 10.3233/JAD-121348. 

Antonenko D, Diekelmann S, Olsen C, Born J, Mölle M. Napping to renew learning capacity: enhanced encoding after stimulation of sleep slow oscillations. Eur J Neurosci. 2013 Apr;37(7):1142-51. doi: 10.1111/ejn.12118. 

Antonenko D, Meinzer M, Lindenberg R, Witte AV, Flöel A. Grammar learning in older adults is linked to white matter microstructure and functional connectivity. Neuroimage. 2012 Sep;62(3):1667-74. doi: 10.1016/j.neuroimage.2012.05.074.

Meinzer M, Flaisch T, Seeds L, Harnish S, Antonenko D, Witte V, Lindenberg R, Crosson B. Same modulation but different starting points: performance modulates age differences in inferior frontal cortex activity during word-retrieval. PLoS One. 2012;7(3):e33631. doi: 10.1371/journal.pone.0033631. 

Meinzer M, Antonenko D, Lindenberg R, Hetzer S, Ulm L, Avirame K, Flaisch T, Flöel A. Electrical brain stimulation improves cognitive performance by modulating functional connectivity and task-specific activation. J Neurosci. 2012 Feb 1;32(5):1859-66. doi: 10.1523/JNEUROSCI.4812-11.2012.